Pre-Conference Workshop Day

Tuesday, June 20

Workshop A

9:00 am Adenosine-Mediated Immune Cell Inhibition

Synopsis

Adenosine’s role in cancer progression is well-explored, but with this amount of data, it can be hard to determine the usable insights. Join this workshop to take a granular look at internal and external adenosine pathways. You will learn Tumor immunosuppression mechanisms and their effects on CD8+ T cells.

  • Focus on the role of enzyme related changes vs. adenosine receptor changes
  • Explore the role of adenosine internally and externally in driving immune suppression and tumor growth and metastasis
  • Highlight the complexity and redundancy of purine-converting pathways in the tumor microenvironment
  • Consider the functions of adenosine kinase as potential therapeutic target 

Workshop B

1:00 pm Hypoxia: Effects & Pathophysiology & Angiogenesis: The key Processes & Inhibition

Synopsis

Explore the processes and causes of hypoxia to improve your understanding of how agiogenesis can be prevented with adenosine therapeutics. Gain the most up to date information on the critical physiological insights from leading academic and clinical expertise. In this workshop you will:

  • Identify and describe the types of tumors that are more or less likely to be hypoxic and how these can be identified
  • Review the impacts of hypoxia on cancer resistance and link to:
  • Adenosine, ATP, A2AR, Adenosine Deaminase, Adenosine Kinase, CD73, CD39 and CD38
  • Revisit the role of adenosine in tumor angiogenesis, the natural drivers, and purine-based inhibitors
  • Discuss how these natural processes can be best co-opted Targeting adenosine metabolism – what are the challenges? 

4:00 pm End of Workshop Day