Dual Blockade of Adenosine and PD-1 Immunosuppression Enhances Chimeric Antigen Receptor T-Cell Therapy

Time: 11:45 am
day: Day Two


• Highlighting immunosuppression within the tumor microenvironment is a major reason underlying poor responses of CAR T-Cell responses in solid tumors

• Showing that dual blockade of adenosine and PD-1 checkpoint pathways significantly enhances CAR T-cell anti-tumor responses in preclinical models