Dual Targeting of CD73 & A2AR for Effective Suppression of Adenosine Signaling

Time: 3:45 pm
day: Day One


• Exploring how inhibitions of either adenosine generation or signaling by inhibiting CD73 or A2AR have been shown to be effective therapeutic approaches

• Analyzing why the co-blockade of CD73 and A2AR results in a more pronounced antitumor activity than blockade of either likely due to increased CD73 expression upon A2AR inhibition and compensatory activity of other adenosine receptors

• Developing small molecule inhibitors that dually target CD73 and A2AR for use in combination with approved immunotherapeutic agents