Preclinical Testing of CD73 or Adora2b Small Molecule Inhibitors in GEM Models of Pancreatic Cancer
Time: 2:00 pm
day: Day One
Details:
- Murine models with high expression of CD73 respond better to CD73 small molecule inhibitors resulting in increased CD8+ T cells
- Targeting the A2B adenosine receptor increases intratumoral CD8+ T cells and may augment the immunomodulating effects of CD73 inhibitors
- GZM+CD8+ T cells in our GEM models expressed high levels of CD73
